Protein Structures, Sequence Alignment and Homology Modeling

This site provides a guide to protein structure and function, including various aspects of structural bioinformatics. It covers some basic principles of protein structure like secondary structure elements, domains and folds, databases, relationships between protein amino acid sequence and the three-dimensional protein structure. In addition, some basics of sequence analysis, homology modeling and structure-based drug design are covered. In the related tutorials I use resources freely available on the web. Although, you should know that there are commercial program packages like Schrödinger, which include many features not available in the free versions. In the experimental part I have included some basics of protein crystallization and protein crystallography.
Kinase structure
The content of this site is merely a collection of lecture notes, it is not a systematic text book on the subject. I do update the text when I see a need for that and I am always glad to receive comments and suggestions. Some features of the site do not show up properly in Internet Explorer 7. Please update to IE 8 or use other browsers, like Safari or Firefox.
Structure-based drug design services by SARomics Biostructures
Structural biology and structure-based drug design outsourcing services
SARomics Biostructures provides a wide range of structural biology services involving custom protein crystallization and protein crystallography, contract drug discovery and structure-based drug design, protein NMR spectroscopy services, etc., please contact us at SARomics Biostructures to discuss your project! The KINOMED Partnership also provides specific services related to kinase drug discovery as well as of-the-shelf kinase structures.